GoodRx vs Cost Plus Drugs: Which Saves You the Most Money on Prescriptions in 2025
A pharmacist compares GoodRx, Cost Plus Drugs, RxSaver, and insurance — and reveals which saves the most money on the most common prescriptions.
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Americans pay 3-5x more for prescriptions than any other country — but there are legitimate ways to dramatically cut your drug costs. A licensed pharmacist breaks down every major discount option.
Cost Plus Drugs (Mark Cuban’s Pharmacy)
Cost Plus Drugs at costplusdrugs.com sells generics at manufacturing cost + 15% markup + $3 pharmacy fee + $5 shipping. For many common generics, this beats everything else. Example: Metformin 500mg (90 tabs) — retail $28, GoodRx $12, Cost Plus $4.70.
GoodRx
Works at 70,000 pharmacies nationwide. Free to use. Best for: brand-name drugs where Cost Plus doesn’t carry them, and for in-store pickup vs. mail-order. Download the app and show the coupon at any participating pharmacy.
Side-by-Side Comparison — 10 Common Drugs
| Drug | Retail | GoodRx | Cost Plus |
|---|---|---|---|
| Metformin 500mg (90) | $28 | $12 | $4.70 |
| Lisinopril 10mg (90) | $24 | $8 | $3.80 |
| Atorvastatin 20mg (90) | $45 | $18 | $5.40 |
| Amoxicillin 500mg (30) | $22 | $9 | $4.20 |